Interaction Interface of Aβ(42) with Human Na,K-ATPase Studied by MD and ITC and Inhibitor Screening by MD

Alzheimer’s disease (AD) is a neurodegenerative disease accompanied by progressive cognitive and memory dysfunction due to disruption of normal electrotonic properties of neurons and neuronal loss. The Na,K-ATPase interaction with beta amyloid (Aβ) plays an important role in AD pathogenesis. It has...

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Detalles Bibliográficos
Autores principales: Adzhubei, Alexei A., Tolstova, Anna P., Strelkova, Maria A., Mitkevich, Vladimir A., Petrushanko, Irina Yu., Makarov, Alexander A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313104/
https://www.ncbi.nlm.nih.gov/pubmed/35884966
http://dx.doi.org/10.3390/biomedicines10071663

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313104/
https://www.ncbi.nlm.nih.gov/pubmed/35884966
http://dx.doi.org/10.3390/biomedicines10071663

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