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Modulating the Fibrillization of Parathyroid-Hormone (PTH) Peptides: Azo-Switches as Reversible and Catalytic Entities

We here report a novel strategy to control the bioavailability of the fibrillizing parathyroid hormone (PTH)-derived peptides, where the concentration of the bioactive form is controlled by an reversible, photoswitchable peptide. PTH(1–84), a human hormone secreted by the parathyroid glands, is impo...

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Detalles Bibliográficos
Autores principales: Paschold, André, Voigt, Bruno, Hause, Gerd, Kohlmann, Tim, Rothemund, Sven, Binder, Wolfgang H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313110/
https://www.ncbi.nlm.nih.gov/pubmed/35884817
http://dx.doi.org/10.3390/biomedicines10071512