Recognition of BRAF by CDC37 and Re-Evaluation of the Activation Mechanism for the Class 2 BRAF-L597R Mutant

The kinome specific co-chaperone, CDC37 (cell division cycle 37), is responsible for delivering BRAF (B-Rapidly Accelerated Fibrosarcoma) to the Hsp90 (heat shock protein 90) complex, where it is then translocated to the RAS (protooncogene product p21) complex at the plasma membrane for RAS mediated...

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Detalles Bibliográficos
Autores principales: Bjorklund, Dennis M., Morgan, R. Marc L., Oberoi, Jasmeen, Day, Katie L. I. M., Galliou, Panagiota A., Prodromou, Chrisostomos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313131/
https://www.ncbi.nlm.nih.gov/pubmed/35883461
http://dx.doi.org/10.3390/biom12070905

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313131/
https://www.ncbi.nlm.nih.gov/pubmed/35883461
http://dx.doi.org/10.3390/biom12070905

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