Calpain-Independent Intracellular Protease Activity Is Elevated in Excitotoxic Cortical Neurons Prior to Delayed Calcium Deregulation and Mitochondrial Dysfunction

Glutamate excitotoxicity contributes to many neurodegenerative diseases. Excessive glutamate receptor-mediated calcium entry causes delayed calcium deregulation (DCD) that coincides with abrupt mitochondrial depolarization. We developed cA-TAT, a live-cell protease activity reporter based on a vimen...

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Detalles Bibliográficos
Autores principales: Polster, Brian M., Mark, Karla A., Arze, Rafael, Hudson, Derek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313431/
https://www.ncbi.nlm.nih.gov/pubmed/35883560
http://dx.doi.org/10.3390/biom12071004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313431/
https://www.ncbi.nlm.nih.gov/pubmed/35883560
http://dx.doi.org/10.3390/biom12071004

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