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Calcium signaling in individual APP/PS1 mouse dentate gyrus astrocytes increases ex vivo with Aβ pathology and age without affecting astrocyte network activity

Astrocytes are critical for healthy brain function. In Alzheimer’s disease, astrocytes become reactive, which affects their signaling properties. Here, we measured spontaneous calcium transients ex vivo in hippocampal astrocytes in brain slices containing the dentate gyrus of 6‐ (6M) and 9‐month‐old...

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Detalles Bibliográficos
Autores principales: Huffels, Christiaan F. M., Osborn, Lana M., Cappaert, Natalie L. M., Hol, Elly M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314019/
https://www.ncbi.nlm.nih.gov/pubmed/35293016
http://dx.doi.org/10.1002/jnr.25042