Cargando…

Microsecond Backbone Motions Modulate the Oligomerization of the DNAJB6 Chaperone

DNAJB6 is a prime example of an anti‐aggregation chaperone that functions as an oligomer. DNAJB6 oligomers are dynamic and subunit exchange is critical for inhibiting client protein aggregation. The T193A mutation in the C‐terminal domain (CTD) of DNAJB6 reduces both chaperone self‐oligomerization a...

Descripción completa

Detalles Bibliográficos
Autores principales: Cawood, Emma E., Clore, G. Marius, Karamanos, Theodoros K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314120/
https://www.ncbi.nlm.nih.gov/pubmed/35247211
http://dx.doi.org/10.1002/anie.202116403