Conjugates of Tacrine with Salicylamide as Promising Multitarget Agents for Alzheimer's Disease

New conjugates of tacrine and salicylamide with alkylene spacers were synthesized and evaluated as potential multifunctional agents for Alzheimer's disease (AD). The compounds exhibited high acetylcholinesterase (AChE, IC(50) to 0.224 μM) and butyrylcholinesterase (BChE, IC(50) to 0.0104 μM) in...

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Detalles Bibliográficos
Autores principales: Grishchenko, Maria V., Makhaeva, Galina F., Burgart, Yanina V., Rudakova, Elena V., Boltneva, Natalia P., Kovaleva, Nadezhda V., Serebryakova, Olga G., Lushchekina, Sofya V., Astakhova, Tatiana Y., Zhilina, Ekaterina F., Shchegolkov, Evgeny V., Richardson, Rudy J., Saloutin, Victor I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314152/
https://www.ncbi.nlm.nih.gov/pubmed/35322571
http://dx.doi.org/10.1002/cmdc.202200080

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314152/
https://www.ncbi.nlm.nih.gov/pubmed/35322571
http://dx.doi.org/10.1002/cmdc.202200080

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