Cargando…

Conjugates of Tacrine with Salicylamide as Promising Multitarget Agents for Alzheimer's Disease

New conjugates of tacrine and salicylamide with alkylene spacers were synthesized and evaluated as potential multifunctional agents for Alzheimer's disease (AD). The compounds exhibited high acetylcholinesterase (AChE, IC(50) to 0.224 μM) and butyrylcholinesterase (BChE, IC(50) to 0.0104 μM) in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Grishchenko, Maria V., Makhaeva, Galina F., Burgart, Yanina V., Rudakova, Elena V., Boltneva, Natalia P., Kovaleva, Nadezhda V., Serebryakova, Olga G., Lushchekina, Sofya V., Astakhova, Tatiana Y., Zhilina, Ekaterina F., Shchegolkov, Evgeny V., Richardson, Rudy J., Saloutin, Victor I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314152/ https://www.ncbi.nlm.nih.gov/pubmed/35322571 http://dx.doi.org/10.1002/cmdc.202200080

Ejemplares similares

Conjugates of Tacrine and Salicylic Acid Derivatives as New Promising Multitarget Agents for Alzheimer’s Disease
por: Makhaeva, Galina F., et al.
Publicado: (2023)

New Multifunctional Agents for Potential Alzheimer’s Disease Treatment Based on Tacrine Conjugates with 2-Arylhydrazinylidene-1,3-Diketones
por: Elkina, Natalia A., et al.
Publicado: (2022)

Bis-Amiridines as Acetylcholinesterase and Butyrylcholinesterase Inhibitors: N-Functionalization Determines the Multitarget Anti-Alzheimer’s Activity Profile
por: Makhaeva, Galina F., et al.
Publicado: (2022)

Synthesis of 4-Aminopyrazol-5-ols as Edaravone Analogs and Their Antioxidant Activity
por: Burgart, Yanina V., et al.
Publicado: (2022)

New Hybrids of 4-Amino-2,3-polymethylene-quinoline and p-Tolylsulfonamide as Dual Inhibitors of Acetyl- and Butyrylcholinesterase and Potential Multifunctional Agents for Alzheimer’s Disease Treatment
por: Makhaeva, Galina F., et al.
Publicado: (2020)

Powerful Potential of Polyfluoroalkyl-Containing 4-Arylhydrazinylidenepyrazol-3-ones for Pharmaceuticals
por: Burgart, Yanina V., et al.
Publicado: (2022)

Novel conjugates of aminoadamantanes with carbazole derivatives as potential multitarget agents for AD treatment
por: Bachurin, Sergey O., et al.
Publicado: (2017)

Derivatives of 9-phosphorylated acridine as butyrylcholinesterase inhibitors with antioxidant activity and the ability to inhibit β-amyloid self-aggregation: potential therapeutic agents for Alzheimer’s disease
por: Makhaeva, Galina F., et al.
Publicado: (2023)

Conjugates of methylene blue with γ-carboline derivatives as new multifunctional agents for the treatment of neurodegenerative diseases
por: Bachurin, Sergey O., et al.
Publicado: (2019)

New Multifunctional Agents Based on Conjugates of 4-Amino-2,3-polymethylenequinoline and Butylated Hydroxytoluene for Alzheimer’s Disease Treatment
por: Makhaeva, Galina F., et al.
Publicado: (2020)

Synthesis of Mono- and Polyazole Hybrids Based on Polyfluoroflavones
por: Panova, Mariya A., et al.
Publicado: (2023)

Conjugation of Aminoadamantane and γ-Carboline Pharmacophores Gives Rise to Unexpected Properties of Multifunctional Ligands
por: Bachurin, Sergey O., et al.
Publicado: (2021)

Conjugates of Methylene Blue with Cycloalkaneindoles as New Multifunctional Agents for Potential Treatment of Neurodegenerative Disease
por: Bachurin, Sergey O., et al.
Publicado: (2022)

Conjugates of γ-Carbolines and Phenothiazine as new selective inhibitors of butyrylcholinesterase and blockers of NMDA receptors for Alzheimer Disease
por: Makhaeva, Galina F., et al.
Publicado: (2015)

Arachidonoylcholine and Other Unsaturated Long-Chain Acylcholines Are Endogenous Modulators of the Acetylcholine Signaling System
por: Akimov, Mikhail G., et al.
Publicado: (2020)

Polyfluoroalkylated antipyrines in Pd-catalyzed transformations
por: Shchegolkov, Evgeny V., et al.
Publicado: (2021)

The reactions of 2-ethoxymethylidene-3-oxo esters and their analogues with 5-aminotetrazole as a way to novel azaheterocycles
por: Goryaeva, Marina V, et al.
Publicado: (2015)

Novel multitarget-directed tacrine derivatives as potential candidates for the treatment of Alzheimer’s disease
por: Wu, Wen-Yu, et al.
Publicado: (2017)

Heterometallic Molecular Architectures Based on Fluorinated β-Diketone Ligands
por: Saloutin, Viktor I., et al.
Publicado: (2022)

New Multitarget Hybrids Bearing Tacrine and Phenylbenzothiazole Motifs as Potential Drug Candidates for Alzheimer’s Disease
por: Rajeshwari, Rajeshwari, et al.
Publicado: (2019)

Merged Tacrine-Based, Multitarget-Directed Acetylcholinesterase Inhibitors 2015–Present: Synthesis and Biological Activity
por: Eckroat, Todd J., et al.
Publicado: (2020)

Region-Specific and Age-Dependent Multitarget Effects of Acetylcholinesterase Inhibitor Tacrine on Comprehensive Neurotransmitter Systems
por: Fridjonsdottir, Elva, et al.
Publicado: (2021)

Pharmacological Potential of Betulin as a Multitarget Compound
por: Adepoju, Feyisayo O., et al.
Publicado: (2023)

Multitarget Drug Design, Molecular Docking and PLIF Studies of Novel Tacrine−Coumarin Hybrids for the Treatment of Alzheimer’s Disease
por: Fereidoonnezhad, Masood, et al.
Publicado: (2018)

Multicomponent Domino Cyclization of Ethyl Trifluoropyruvate with Methyl Ketones and Amino Alcohols as A New Way to γ-Lactam Annulated Oxazacycles
por: Goryaeva, Marina V., et al.
Publicado: (2023)

Modified Tacrine Derivatives as Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease: Synthesis, Biological Evaluation, and Molecular Modeling Study
por: Fares, Salma, et al.
Publicado: (2023)

7-Imidazolyl-substituted 4'-methoxy and 3',4'-dimethoxy-containing polyfluoroflavones as promising antiviral agents
por: Shcherbakov, Konstantin V., et al.
Publicado: (2020)

Water structure changes in oxime-mediated reactivation process of phosphorylated human acetylcholinesterase
por: Zueva, Irina V., et al.
Publicado: (2018)

Steady-State Kinetics of Enzyme-Catalyzed Hydrolysis of Echothiophate, a P–S Bonded Organophosphorus as Monitored by Spectrofluorimetry
por: Zueva, Irina V., et al.
Publicado: (2020)

Salicylamide Enhances Melanin Synthesis in B16F1 Melanoma Cells
por: Ito, Yusuke, et al.
Publicado: (2021)

Coexistence of Intra- and Intermolecular Hydrogen Bonds: Salicylic Acid and Salicylamide and Their Thiol Counterparts
por: Gholami, Samira, et al.
Publicado: (2021)

New Screening Protocol for Effective Green Solvents Selection of Benzamide, Salicylamide and Ethenzamide
por: Przybyłek, Maciej, et al.
Publicado: (2022)

1-(3-Tert-Butylphenyl)-2,2,2-Trifluoroethanone as a Potent Transition-State Analogue Slow-Binding Inhibitor of Human Acetylcholinesterase: Kinetic, MD and QM/MM Studies
por: Zueva, Irina V., et al.
Publicado: (2020)

Neuroprotective derivatives of tacrine that target NMDA receptor and acetyl cholinesterase – Design, synthesis and biological evaluation
por: Remya, Chandran, et al.
Publicado: (2021)

Therapeutic Potential of Multifunctional Tacrine Analogues
por: Przybyłowska, Maja, et al.
Publicado: (2019)

Enantioselective Michael Addition of Aldehydes to Maleimides Organocatalyzed by a Chiral Primary Amine-Salicylamide
por: Torregrosa-Chinillach, Alejandro, et al.
Publicado: (2018)

Asymmetric Conjugate Addition of Ketones to Maleimides Organocatalyzed by a Chiral Primary Amine-Salicylamide
por: Torregrosa-Chinillach, Alejandro, et al.
Publicado: (2022)

Facile synthesis of 6-organyl-4-(trifluoromethyl)pyridin-2(1H)-ones and their polyfluoroalkyl-containing analogs
por: Kushch, S. O., et al.
Publicado: (2022)

Changes in the Electrophysical Parameters of Nanomodified Elastomers Caused by Electric Current’s Passage
por: Shchegolkov, Alexandr V., et al.
Publicado: (2023)

Recent Advantages on Waste Management in Hydrogen Industry
por: Shchegolkov, Alexander V., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_68deae8nv7aoc869k2p9mq623v