Quantitation of methotrexate polyglutamates in human whole blood, erythrocytes and leukocytes collected via venepuncture and volumetric absorptive micro-sampling: a green LC–MS/MS-based method

Low-dose methotrexate (MTX) plays a key role in treatment of rheumatoid arthritis. However, not all patients respond satisfactorily, and no therapeutic drug monitoring has been implemented in clinical practice, despite the fact that MTX therapy has now been available for decades. Analysis of individ...

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Detalles Bibliográficos
Autores principales: Daraghmeh, Dala N., Moghaddami, Mahin, Bobrovskaya, Larisa, Proudman, Susanna M., Wiese, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Paper in Forefront
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314280/
https://www.ncbi.nlm.nih.gov/pubmed/35796782
http://dx.doi.org/10.1007/s00216-022-04186-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314280/
https://www.ncbi.nlm.nih.gov/pubmed/35796782
http://dx.doi.org/10.1007/s00216-022-04186-1

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