Targeting lactate dehydrogenase B-dependent mitochondrial metabolism affects tumor initiating cells and inhibits tumorigenesis of non-small cell lung cancer by inducing mtDNA damage

Once considered a waste product of anaerobic cellular metabolism, lactate has been identified as a critical regulator of tumorigenesis, maintenance, and progression. The putative primary function of lactate dehydrogenase B (LDHB) is to catalyze the conversion of lactate to pyruvate; however, its rol...

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Detalles Bibliográficos
Autores principales: Deng, Haibin, Gao, Yanyun, Trappetti, Verdiana, Hertig, Damian, Karatkevich, Darya, Losmanova, Tereza, Urzi, Christian, Ge, Huixiang, Geest, Gerrit Adriaan, Bruggmann, Remy, Djonov, Valentin, Nuoffer, Jean-Marc, Vermathen, Peter, Zamboni, Nicola, Riether, Carsten, Ochsenbein, Adrian, Peng, Ren-Wang, Kocher, Gregor Jan, Schmid, Ralph Alexander, Dorn, Patrick, Marti, Thomas Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314287/
https://www.ncbi.nlm.nih.gov/pubmed/35877003
http://dx.doi.org/10.1007/s00018-022-04453-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314287/
https://www.ncbi.nlm.nih.gov/pubmed/35877003
http://dx.doi.org/10.1007/s00018-022-04453-5

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