Phenylalanine impairs insulin signaling and inhibits glucose uptake through modification of IRβ

Whether amino acids act on cellular insulin signaling remains unclear, given that increased circulating amino acid levels are associated with the onset of type 2 diabetes (T2D). Here, we report that phenylalanine modifies insulin receptor beta (IRβ) and inactivates insulin signaling and glucose upta...

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Detalles Bibliográficos
Autores principales: Zhou, Qian, Sun, Wan-Wan, Chen, Jia-Cong, Zhang, Hui-Lu, Liu, Jie, Lin, Yan, Lin, Peng-Cheng, Wu, Bai-Xing, An, Yan-Peng, Huang, Lin, Sun, Wen-Xing, Zhou, Xin-Wen, Li, Yi-Ming, Yuan, Yi-Yuan, Zhao, Jian-Yuan, Xu, Wei, Zhao, Shi-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314339/
https://www.ncbi.nlm.nih.gov/pubmed/35879296
http://dx.doi.org/10.1038/s41467-022-32000-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314339/
https://www.ncbi.nlm.nih.gov/pubmed/35879296
http://dx.doi.org/10.1038/s41467-022-32000-0

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