The architecture of kinesin-3 KLP-6 reveals a multilevel-lockdown mechanism for autoinhibition

Autoinhibition of kinesin-3 ensures the proper spatiotemporal control of the motor activity for intracellular transport, but the underlying mechanism remains elusive. Here, we determine the full-length structure of kinesin-3 KLP-6 in a compact self-folded state. Unexpectedly, all the internal coiled...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Wenjuan, Ren, Jinqi, Song, Weiye, Zhang, Yong, Feng, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314371/
https://www.ncbi.nlm.nih.gov/pubmed/35879313
http://dx.doi.org/10.1038/s41467-022-32048-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314371/
https://www.ncbi.nlm.nih.gov/pubmed/35879313
http://dx.doi.org/10.1038/s41467-022-32048-y

Ejemplares similares