DNA nicks induce mutational signatures associated with BRCA1 deficiency

Analysis of human cancer genome sequences has revealed specific mutational signatures associated with BRCA1-deficient tumors, but the underlying mechanisms remain poorly understood. Here, we show that one-ended DNA double strand breaks (DSBs) converted from CRISPR/Cas9-induced nicks by DNA replicati...

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Detalles Bibliográficos
Autores principales: Feng, Yi-Li, Liu, Qian, Chen, Ruo-Dan, Liu, Si-Cheng, Huang, Zhi-Cheng, Liu, Kun-Ming, Yang, Xiao-Ying, Xie, An-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314409/
https://www.ncbi.nlm.nih.gov/pubmed/35879372
http://dx.doi.org/10.1038/s41467-022-32011-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314409/
https://www.ncbi.nlm.nih.gov/pubmed/35879372
http://dx.doi.org/10.1038/s41467-022-32011-x

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