Regulated degradation of HMG CoA reductase requires conformational changes in sterol-sensing domain

3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) is the rate-limiting enzyme in cholesterol synthesis and target of cholesterol-lowering statin drugs. Accumulation of sterols in endoplasmic reticulum (ER) membranes accelerates degradation of HMGCR, slowing the synthesis of cholesterol. Degrad...

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Detalles Bibliográficos
Autores principales: Chen, Hongwen, Qi, Xiaofeng, Faulkner, Rebecca A., Schumacher, Marc M., Donnelly, Linda M., DeBose-Boyd, Russell A., Li, Xiaochun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314443/
https://www.ncbi.nlm.nih.gov/pubmed/35879350
http://dx.doi.org/10.1038/s41467-022-32025-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314443/
https://www.ncbi.nlm.nih.gov/pubmed/35879350
http://dx.doi.org/10.1038/s41467-022-32025-5

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