Extreme purifying selection against point mutations in the human genome

Large-scale genome sequencing has enabled the measurement of strong purifying selection in protein-coding genes. Here we describe a new method, called ExtRaINSIGHT, for measuring such selection in noncoding as well as coding regions of the human genome. ExtRaINSIGHT estimates the prevalence of “ultr...

Descripción completa

Detalles Bibliográficos
Autores principales: Dukler, Noah, Mughal, Mehreen R., Ramani, Ritika, Huang, Yi-Fei, Siepel, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314448/
https://www.ncbi.nlm.nih.gov/pubmed/35879308
http://dx.doi.org/10.1038/s41467-022-31872-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314448/
https://www.ncbi.nlm.nih.gov/pubmed/35879308
http://dx.doi.org/10.1038/s41467-022-31872-6

Ejemplares similares