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Extreme purifying selection against point mutations in the human genome

Large-scale genome sequencing has enabled the measurement of strong purifying selection in protein-coding genes. Here we describe a new method, called ExtRaINSIGHT, for measuring such selection in noncoding as well as coding regions of the human genome. ExtRaINSIGHT estimates the prevalence of “ultr...

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Detalles Bibliográficos
Autores principales:	Dukler, Noah, Mughal, Mehreen R., Ramani, Ritika, Huang, Yi-Fei, Siepel, Adam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314448/ https://www.ncbi.nlm.nih.gov/pubmed/35879308 http://dx.doi.org/10.1038/s41467-022-31872-6

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