HEPES‐buffering of bicarbonate‐containing culture medium perturbs lysosomal glucocerebrosidase activity

Glucocerebrosidase (GCase), encoded by the GBA gene, degrades the ubiquitous glycosphingolipid glucosylceramide. Inherited GCase deficiency causes Gaucher disease (GD). In addition, carriers of an abnormal GBA allele are at increased risk for Parkinson's disease. GCase undergoes extensive modif...

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Detalles Bibliográficos
Autores principales: van der Lienden, Martijn J. C., Aten, Jan, Boot, Rolf G., van Eijk, Marco, Aerts, Johannes M. F. G., Kuo, Chi‐Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314694/
https://www.ncbi.nlm.nih.gov/pubmed/35312102
http://dx.doi.org/10.1002/jcb.30234

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314694/
https://www.ncbi.nlm.nih.gov/pubmed/35312102
http://dx.doi.org/10.1002/jcb.30234

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