The respiratory depressant effects of mitragynine are limited by its conversion to 7‐OH mitragynine

BACKGROUND AND PURPOSE: Mitragynine, the major alkaloid in Mitragyna speciosa (kratom), is a partial agonist at the μ opioid receptor. CYP3A‐dependent oxidation of mitragynine yields the metabolite 7‐OH mitragynine, a more efficacious μ receptor agonist. While both mitragynine and 7‐OH mitragynine c...

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Detalles Bibliográficos
Autores principales: Hill, Rob, Kruegel, Andrew C., Javitch, Jonathan A., Lane, J. Robert, Canals, Meritxell
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314834/
https://www.ncbi.nlm.nih.gov/pubmed/35297034
http://dx.doi.org/10.1111/bph.15832

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314834/
https://www.ncbi.nlm.nih.gov/pubmed/35297034
http://dx.doi.org/10.1111/bph.15832

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