P2X2 receptor subunit interfaces are missense variant hotspots, where mutations tend to increase apparent ATP affinity

BACKGROUND AND PURPOSE: P2X receptors are trimeric ligand‐gated ion channels that open a cation‐selective pore in response to ATP binding to their large extracellular domain. The seven known P2X subtypes can assemble as homotrimeric or heterotrimeric complexes and contribute to numerous physiologica...

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Detalles Bibliográficos
Autores principales: Gasparri, Federica, Sarkar, Debayan, Bielickaite, Sarune, Poulsen, Mette Homann, Hauser, Alexander Sebastian, Pless, Stephan Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314836/
https://www.ncbi.nlm.nih.gov/pubmed/35285517
http://dx.doi.org/10.1111/bph.15830

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314836/
https://www.ncbi.nlm.nih.gov/pubmed/35285517
http://dx.doi.org/10.1111/bph.15830

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