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P2X2 receptor subunit interfaces are missense variant hotspots, where mutations tend to increase apparent ATP affinity
BACKGROUND AND PURPOSE: P2X receptors are trimeric ligand‐gated ion channels that open a cation‐selective pore in response to ATP binding to their large extracellular domain. The seven known P2X subtypes can assemble as homotrimeric or heterotrimeric complexes and contribute to numerous physiologica...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314836/ https://www.ncbi.nlm.nih.gov/pubmed/35285517 http://dx.doi.org/10.1111/bph.15830 |