Cargando…

The two pore potassium channel THIK‐1 regulates NLRP3 inflammasome activation

The NLRP3 (NLR family, pyrin domain containing 3) inflammasome is a multi‐protein complex responsible for the activation of caspase‐1 and the subsequent cleavage and activation of the potent proinflammatory cytokines IL‐1β and IL‐18, and pyroptotic cell death. NLRP3 is implicated as a driver of infl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Drinkall, Samuel, Lawrence, Catherine B., Ossola, Bernadino, Russell, Samuel, Bender, Clare, Brice, Nicola B., Dawson, Lee A., Harte, Michael, Brough, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314991/ https://www.ncbi.nlm.nih.gov/pubmed/35353387 http://dx.doi.org/10.1002/glia.24174

Ejemplares similares

Characterisation of C101248: A novel selective THIK-1 channel inhibitor for the modulation of microglial NLRP3-inflammasome
por: Ossola, Bernardino, et al.
Publicado: (2023)

Regulation of the two-pore domain potassium channel, THIK-1 and THIK-2, by G protein coupled receptors
por: Tateyama, Michihiro, et al.
Publicado: (2023)

Synapse development is regulated by microglial THIK-1 K(+) channels
por: Izquierdo, Pablo, et al.
Publicado: (2021)

Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K(+) Channel THIK-1
por: Madry, Christian, et al.
Publicado: (2018)

Inhibiting the NLRP3 Inflammasome
por: El-Sharkawy, Lina Y., et al.
Publicado: (2020)

Boron-Based Inhibitors of the NLRP3 Inflammasome
por: Baldwin, Alex G., et al.
Publicado: (2017)

Inhibition of the NLRP3 inflammasome by HSP90 inhibitors
por: Nizami, Sohaib, et al.
Publicado: (2020)

Long-pore Electrostatics in Inward-rectifier Potassium Channels
por: Robertson, Janice L., et al.
Publicado: (2008)

Electrostatics and the Gating Pore of Shaker Potassium Channels
por: Islas, Leon D., et al.
Publicado: (2001)

Two-pore Domain Potassium Channels in Astrocytes
por: Ryoo, Kanghyun, et al.
Publicado: (2016)

Pore size matters for potassium channel conductance
por: Naranjo, David, et al.
Publicado: (2016)

Endosomal trafficking of two-pore K(+) efflux channel TWIK2 to plasmalemma mediates NLRP3 inflammasome activation and inflammatory injury
por: Huang, Long Shuang, et al.
Publicado: (2023)

The NLRP3–inflammasome as a sensor of organelle dysfunction
por: Seoane, Paula I., et al.
Publicado: (2020)

Alum Activates the Bovine NLRP3 Inflammasome
por: Harte, Ciaran, et al.
Publicado: (2017)

Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models
por: Daniels, Michael J. D., et al.
Publicado: (2016)

The pore-forming subunit Kir6.1 of the K-ATP channel negatively regulates the NLRP3 inflammasome to control insulin resistance by interacting with NLRP3
por: Du, Ren-Hong, et al.
Publicado: (2019)

Potassium channels as multi-ion single-file pores
Publicado: (1978)

Trafficking of Neuronal Two Pore Domain Potassium Channels
por: Mathie, Alistair, et al.
Publicado: (2010)

Two-pore domain potassium channels in the adrenal cortex
por: Bandulik, Sascha, et al.
Publicado: (2014)

Tandem pore TWIK-related potassium channels and neuroprotection
por: Lamas, J. Antonio, et al.
Publicado: (2019)

Potassium-dependent Changes in the Conformation of the Kv2.1 Potassium Channel Pore
por: Immke, David, et al.
Publicado: (1999)

Distinct Molecular Mechanisms Underlying Potassium Efflux for NLRP3 Inflammasome Activation
por: Xu, Ziwei, et al.
Publicado: (2020)

The potential convergence of NLRP3 inflammasome, potassium, and dopamine mechanisms in Parkinson’s disease
por: Pike, Adrianne F., et al.
Publicado: (2022)

Design, Synthesis and Evaluation of Oxazaborine Inhibitors of the NLRP3 Inflammasome
por: Baldwin, Alex G., et al.
Publicado: (2018)

Investigating Markers of the NLRP3 Inflammasome Pathway in Alzheimer’s Disease: A Human Post-Mortem Study
por: Tang, Hao, et al.
Publicado: (2021)

Two-pore domain potassium channels enable action potential generation in the absence of voltage-gated potassium channels
por: MacKenzie, Georgina, et al.
Publicado: (2014)

Relationship between Pore Occupancy and Gating in BK Potassium Channels
por: Piskorowski, Rebecca A., et al.
Publicado: (2006)

Vibrio pore-forming leukocidin activates pyroptotic cell death via the NLRP3 inflammasome
por: Cohen, Hadar, et al.
Publicado: (2020)

SARS-COV-2 viroporins activate the NLRP3-inflammasome by the mitochondrial permeability transition pore
por: Guarnieri, Joseph W., et al.
Publicado: (2023)

Neurodegenerative Disease and the NLRP3 Inflammasome
por: Holbrook, Jonathan A., et al.
Publicado: (2021)

Sphingosine regulates the NLRP3-inflammasome and IL-1β release from macrophages
por: Luheshi, Nadia M, et al.
Publicado: (2012)

Itaconate and fumarate derivatives inhibit priming and activation of the canonical NLRP3 inflammasome in macrophages
por: Hoyle, Christopher, et al.
Publicado: (2022)

Hallmarks of NLRP3 inflammasome activation are observed in organotypic hippocampal slice culture
por: Hoyle, Christopher, et al.
Publicado: (2020)

Priming Is Dispensable for NLRP3 Inflammasome Activation in Human Monocytes In Vitro
por: Gritsenko, Anna, et al.
Publicado: (2020)

The NLRP6 inflammasome
por: Zheng, Danping, et al.
Publicado: (2020)

Nonindependent K(+) Movement through the Pore in IRK1 Potassium Channels
por: Stampe, Per, et al.
Publicado: (1998)

The pore of voltage-gated potassium ion channels is strained when closed
por: Fowler, Philip W., et al.
Publicado: (2013)

Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses
por: Redondo-Castro, Elena, et al.
Publicado: (2018)

USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation
por: Palazón‐Riquelme, Pablo, et al.
Publicado: (2018)

LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation
por: Green, Jack P, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_hphq7vfvt2keu4u4nke5ludq13