Investigation of Carboxylic Acid Isosteres and Prodrugs for Inhibition of the Human SIRT5 Lysine Deacylase Enzyme

Sirtuin 5 (SIRT5) is a protein lysine deacylase enzyme that regulates diverse biology by hydrolyzing ϵ‐N‐carboxyacyllysine posttranslational modifications in the cell. Inhibition of SIRT5 has been linked to potential treatment of several cancers but potent compounds with activity in cells have been...

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Detalles Bibliográficos
Autores principales: Rajabi, Nima, Hansen, Tobias N., Nielsen, Alexander L., Nguyen, Huy T., Bæk, Michael, Bolding, Julie. E., Bahlke, Oskar Ø., Petersen, Sylvester E. G., Bartling, Christian R. O., Strømgaard, Kristian, Olsen, Christian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315039/
https://www.ncbi.nlm.nih.gov/pubmed/35299278
http://dx.doi.org/10.1002/anie.202115805

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315039/
https://www.ncbi.nlm.nih.gov/pubmed/35299278
http://dx.doi.org/10.1002/anie.202115805

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