Ablation of high‐mobility group box‐1 in the liver reduces hepatocellular carcinoma but causes hyperbilirubinemia in Hippo signaling‐deficient mice

Silencing the Hippo kinases mammalian sterile 20‐like 1 and 2 (MST1/2) activates the transcriptional coactivator yes‐associated protein (YAP) in human hepatocellular carcinoma (HCC). Hepatocyte‐derived high‐mobility group box‐1 (HMGB1) regulates YAP expression; however, its contribution to HCC in th...

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Detalles Bibliográficos
Autores principales: Athavale, Dipti, Song, Zhuolun, Desert, Romain, Han, Hui, Das, Sukanta, Ge, Xiaodong, Komakula, Sai Santosh Babu, Chen, Wei, Gao, Shenglan, Lantvit, Daniel, Guzman, Grace, Nieto, Natalia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315122/
https://www.ncbi.nlm.nih.gov/pubmed/35344292
http://dx.doi.org/10.1002/hep4.1943

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315122/
https://www.ncbi.nlm.nih.gov/pubmed/35344292
http://dx.doi.org/10.1002/hep4.1943

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