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Ablation of high‐mobility group box‐1 in the liver reduces hepatocellular carcinoma but causes hyperbilirubinemia in Hippo signaling‐deficient mice
Silencing the Hippo kinases mammalian sterile 20‐like 1 and 2 (MST1/2) activates the transcriptional coactivator yes‐associated protein (YAP) in human hepatocellular carcinoma (HCC). Hepatocyte‐derived high‐mobility group box‐1 (HMGB1) regulates YAP expression; however, its contribution to HCC in th...
Autores principales: | Athavale, Dipti, Song, Zhuolun, Desert, Romain, Han, Hui, Das, Sukanta, Ge, Xiaodong, Komakula, Sai Santosh Babu, Chen, Wei, Gao, Shenglan, Lantvit, Daniel, Guzman, Grace, Nieto, Natalia |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315122/ https://www.ncbi.nlm.nih.gov/pubmed/35344292 http://dx.doi.org/10.1002/hep4.1943 |
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