Cargando…
Length-dependent RNA foci formation and Repeat Associated non-AUG dependent translation in a C. elegans G (4) C (2) model
GC-rich repeat expansion mutations are implicated in several neurodegenerative diseases and can lead to repeat associated non-AUG-dependent (RAN) translation and concentrations of nuclear RNA foci. To model C9orf72 ALS/FTD, we engineered C. elegans to express pure GGGGCC (G (4) C (2) ) repeats of va...
| Autor principal: | |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Caltech Library
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315403/ https://www.ncbi.nlm.nih.gov/pubmed/35903771 http://dx.doi.org/10.17912/micropub.biology.000600 |