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An assessment of genome-editing efficiency of a newly developed Cas9 in C. elegans

Minimizing the off-target effects of the programmable genome editing tool CRISPR/Cas9 is critical for its potential therapeutic applications. A recent study reported a new Cas9 variant, SuperFi-Cas9, that dramatically reduces off-target DNA cleavage while retaining on-target DNA cleavage activity in...

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Detalles Bibliográficos
Autores principales:	Ferdousy, Sakia, Chen, Bojun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Caltech Library 2022
Materias:	Negative Result
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315413/ https://www.ncbi.nlm.nih.gov/pubmed/35903778 http://dx.doi.org/10.17912/micropub.biology.000601

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