Phosphomimetic S207D Lysyl–tRNA Synthetase Binds HIV-1 5′UTR in an Open Conformation and Increases RNA Dynamics

Interactions between lysyl–tRNA synthetase (LysRS) and HIV-1 Gag facilitate selective packaging of the HIV-1 reverse transcription primer, tRNA(Lys3). During HIV-1 infection, LysRS is phosphorylated at S207, released from a multi-aminoacyl–tRNA synthetase complex and packaged into progeny virions. L...

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Detalles Bibliográficos
Autores principales: Cantara, William A., Pathirage, Chathuri, Hatterschide, Joshua, Olson, Erik D., Musier-Forsyth, Karin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315659/
https://www.ncbi.nlm.nih.gov/pubmed/35891536
http://dx.doi.org/10.3390/v14071556

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315659/
https://www.ncbi.nlm.nih.gov/pubmed/35891536
http://dx.doi.org/10.3390/v14071556

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