Preclinical Drug Pharmacokinetic, Tissue Distribution and Excretion Profiles of the Novel Limonin Derivate HY-071085 as an Anti-Inflammatory and Analgesic Candidate in Rats and Beagle Dogs

Limonin is one of the research hotspots in natural drug development. However, its low solubility in water leads to poor oral bioavailability, discouraging the further study of its potential as a candidate compound. In order to overcome this limitation, and to enhance its biological activities, a nov...

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Detalles Bibliográficos
Autores principales: Dong, Liping, Liu, Wenjuan, Zhao, Xiaoyuan, Yu, Feng, Xu, Yungen, Su, Mengxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316000/
https://www.ncbi.nlm.nih.gov/pubmed/35890101
http://dx.doi.org/10.3390/ph15070801