ATR Contributes More Than ATM in Intra-S-Phase Checkpoint Activation after IR, and DNA-PKcs Facilitates Recovery: Evidence for Modular Integration of ATM/ATR/DNA-PKcs Functions

The intra-S-phase checkpoint was among the first reported cell cycle checkpoints in mammalian cells. It transiently slows down the rate of DNA replication after DNA damage to facilitate repair and thus prevents genomic instability. The ionizing radiation (IR)-induced intra-S-phase checkpoint in mamm...

Descripción completa

Detalles Bibliográficos
Autores principales: Soni, Aashish, Duan, Xiaolu, Stuschke, Martin, Iliakis, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316047/
https://www.ncbi.nlm.nih.gov/pubmed/35886852
http://dx.doi.org/10.3390/ijms23147506

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316047/
https://www.ncbi.nlm.nih.gov/pubmed/35886852
http://dx.doi.org/10.3390/ijms23147506

Ejemplares similares