Sphingosine Phosphate Lyase Is Upregulated in Duchenne Muscular Dystrophy, and Its Inhibition Early in Life Attenuates Inflammation and Dystrophy in Mdx Mice

Duchenne muscular dystrophy (DMD) is a congenital myopathy caused by mutations in the dystrophin gene. DMD pathology is marked by myositis, muscle fiber degeneration, and eventual muscle replacement by fibrosis and adipose tissue. Satellite cells (SC) are muscle stem cells critical for muscle regene...

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Detalles Bibliográficos
Autores principales: De la Garza-Rodea, Anabel S., Moore, Steven A., Zamora-Pineda, Jesus, Hoffman, Eric P., Mistry, Karishma, Kumar, Ashok, Strober, Jonathan B., Zhao, Piming, Suh, Jung H., Saba, Julie D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316262/
https://www.ncbi.nlm.nih.gov/pubmed/35886926
http://dx.doi.org/10.3390/ijms23147579

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316262/
https://www.ncbi.nlm.nih.gov/pubmed/35886926
http://dx.doi.org/10.3390/ijms23147579

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