Tetrazine-Induced Bioorthogonal Activation of Vitamin E-Modified siRNA for Gene Silencing

The temporal activation of siRNA provides a valuable strategy for the regulation of siRNA activity and conditional gene silencing. The bioorthogonal bond-cleavage reaction of benzonorbonadiene and tetrazine is a promising trigger in siRNA temporal activation. Here, we developed a new method for the...

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Detalles Bibliográficos
Autores principales: Zhang, Xueli, Gubu, Amu, Xu, Jianfei, Yan, Ning, Su, Wenbo, Feng, Di, Wang, Qian, Tang, Xinjing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316517/
https://www.ncbi.nlm.nih.gov/pubmed/35889249
http://dx.doi.org/10.3390/molecules27144377

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316517/
https://www.ncbi.nlm.nih.gov/pubmed/35889249
http://dx.doi.org/10.3390/molecules27144377

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