Synthesis and Evaluation of Anti-HIV Activity of Mono- and Di-Substituted Phosphonamidate Conjugates of Tenofovir

The activity of nucleoside and nucleotide analogs as antiviral agents requires phosphorylation by endogenous enzymes. Phosphate-substituted analogs have low bioavailability due to the presence of ionizable negatively-charged groups. To circumvent these limitations, several prodrug approaches have be...

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Detalles Bibliográficos
Autores principales: Qureshi, Aaminat, Ouattara, Louise A., El-Sayed, Naglaa Salem, Verma, Amita, Doncel, Gustavo F., Choudhary, Muhammad Iqbal, Siddiqui, Hina, Parang, Keykavous
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316519/
https://www.ncbi.nlm.nih.gov/pubmed/35889320
http://dx.doi.org/10.3390/molecules27144447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316519/
https://www.ncbi.nlm.nih.gov/pubmed/35889320
http://dx.doi.org/10.3390/molecules27144447

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