Use of Biomarker Data and Relative Potencies of Mutagenic Metabolites to Support Derivation of Cancer Unit Risk Values for 1,3-Butadiene from Rodent Tumor Data

Unit Risk (UR) values were derived for 1,3-butadiene (BD) based upon its ability to cause tumors in laboratory mice and rats. Metabolism has been established as the significant molecular initiating event of BD’s carcinogenicity. The large quantitative species differences in the metabolism of BD and...

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Detalles Bibliográficos
Autores principales: Kirman, Christopher R., Hays, Sean M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316621/
https://www.ncbi.nlm.nih.gov/pubmed/35878299
http://dx.doi.org/10.3390/toxics10070394

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316621/
https://www.ncbi.nlm.nih.gov/pubmed/35878299
http://dx.doi.org/10.3390/toxics10070394

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