A Method for In Situ Reverse Genetic Analysis of Proteins Involved mtDNA Replication

The unavailability of tractable reverse genetic analysis approaches represents an obstacle to a better understanding of mitochondrial DNA replication. Here, we used CRISPR-Cas9 mediated gene editing to establish the conditional viability of knockouts in the key proteins involved in mtDNA replication...

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Detalles Bibliográficos
Autores principales: Kozhukhar, Natalya, Spadafora, Domenico, Rodriguez, Yelitza A. R., Alexeyev, Mikhail F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316749/
https://www.ncbi.nlm.nih.gov/pubmed/35883613
http://dx.doi.org/10.3390/cells11142168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316749/
https://www.ncbi.nlm.nih.gov/pubmed/35883613
http://dx.doi.org/10.3390/cells11142168

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