Krüppel-like factor 5 accelerates the pathogenesis of Alzheimer’s disease via BACE1-mediated APP processing

BACKGROUND: The deposition of β-amyloid (Aβ) in the brain plays a major role in the pathogenesis of Alzheimer’s disease (AD). Aβ is generated via amyloid precursor protein (APP) cleavage through the amyloidogenic pathway. In this pathway, β-secretase (BACE1) is the first and rate-limiting enzyme. It...

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Detalles Bibliográficos
Autores principales: Wang, Yaqi, Cui, Yuting, Liu, Jing, Song, Qiao, Cao, Min, Hou, Yuli, Zhang, Xiaomin, Wang, Peichang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316766/
https://www.ncbi.nlm.nih.gov/pubmed/35883144
http://dx.doi.org/10.1186/s13195-022-01050-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316766/
https://www.ncbi.nlm.nih.gov/pubmed/35883144
http://dx.doi.org/10.1186/s13195-022-01050-3

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