Engineering of a Long-Acting Bone Morphogenetic Protein-7 by Fusion with Albumin for the Treatment of Renal Injury

The bone morphogenetic protein-7 (BMP7) is capable of inhibiting TGF-β/Smad3 signaling, which subsequently results in protecting the kidney from renal fibrosis, but its lower blood retention and osteogenic activity are bottlenecks for its clinical application. We report herein on the fusion of carbo...

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Detalles Bibliográficos
Autores principales: Takano, Mei, Toda, Shota, Watanabe, Hiroshi, Fujimura, Rui, Nishida, Kento, Bi, Jing, Minayoshi, Yuki, Miyahisa, Masako, Maeda, Hitoshi, Maruyama, Toru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316787/
https://www.ncbi.nlm.nih.gov/pubmed/35890230
http://dx.doi.org/10.3390/pharmaceutics14071334

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316787/
https://www.ncbi.nlm.nih.gov/pubmed/35890230
http://dx.doi.org/10.3390/pharmaceutics14071334

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