Novel p38 Mitogen-Activated Protein Kinase Inhibitor Reverses Hypoxia-Induced Pulmonary Arterial Hypertension in Rats

Mitogen-activated protein kinase (MAPK) signaling is strongly implicated in cardiovascular remodeling in pulmonary hypertension (PH) and right ventricle (RV) failure. The effects of a newly designed p38 inhibitor, LASSBio-1824, were investigated in experimentally induced PH. Male Wistar rats were ex...

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Detalles Bibliográficos
Autores principales: Silva, Grazielle Fernandes, da Silva, Jaqueline Soares, de Alencar, Allan Kardec Nogueira, de Moraes Carvalho da Silva, Marina, Montagnoli, Tadeu Lima, de Souza Rocha, Bruna, de Freitas, Rosana Helena Coimbra Nogueira, Sudo, Roberto Takashi, Fraga, Carlos Alberto Manssour, Zapata-Sudo, Gisele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316801/
https://www.ncbi.nlm.nih.gov/pubmed/35890198
http://dx.doi.org/10.3390/ph15070900

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316801/
https://www.ncbi.nlm.nih.gov/pubmed/35890198
http://dx.doi.org/10.3390/ph15070900

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