Cargando…

Co-Delivery of Repurposing Itraconazole and VEGF siRNA by Composite Nanoparticulate System for Collaborative Anti-Angiogenesis and Anti-Tumor Efficacy against Breast Cancer

Combinations of two different therapeutic modalities of VEGF inhibitors against angiogenesis can cooperatively impede breast cancer tumor growth and enhance therapeutic efficacy. Itraconazole (ITZ) is a conventional antifungal drug with high safety; however, it has been repurposed to be a multi targ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jin, Mingji, Zeng, Bowen, Liu, Yanhong, Jin, Lili, Hou, Yan, Liu, Chao, Liu, Wei, Wu, Hao, Chen, Liqing, Gao, Zhonggao, Huang, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317122/ https://www.ncbi.nlm.nih.gov/pubmed/35890264 http://dx.doi.org/10.3390/pharmaceutics14071369

Ejemplares similares

Smart Polymeric Nanoparticles with pH-Responsive and PEG-Detachable Properties (II): Co-Delivery of Paclitaxel and VEGF siRNA for Synergistic Breast Cancer Therapy in Mice
por: Jin, Mingji, et al.
Publicado: (2021)

Smart polymeric nanoparticles with pH-responsive and PEG-detachable properties for co-delivering paclitaxel and survivin siRNA to enhance antitumor outcomes
por: Jin, Mingji, et al.
Publicado: (2018)

Development and Evaluation of a PSMA-Targeted Nanosystem Co-Packaging Docetaxel and Androgen Receptor siRNA for Castration-Resistant Prostate Cancer Treatment
por: Zhang, Yingying, et al.
Publicado: (2022)

Improving the anti-keloid outcomes through liposomes loading paclitaxel–cholesterol complexes
por: Wang, Mengjiao, et al.
Publicado: (2019)

Repurposing Drugs in Oncology (ReDO)—itraconazole as an anti-cancer agent
por: Pantziarka, Pan, et al.
Publicado: (2015)

Chitosan-based nanoparticles for survivin targeted siRNA delivery in breast tumor therapy and preventing its metastasis
por: Sun, Ping, et al.
Publicado: (2016)

Topical Application of JAK1/JAK2 Inhibitor Momelotinib Exhibits Significant Anti-Inflammatory Responses in DNCB-Induced Atopic Dermatitis Model Mice
por: Jin, Wenyu, et al.
Publicado: (2018)

Systemic siRNA Delivery with a Dual pH-Responsive and Tumor-targeted Nanovector for Inhibiting Tumor Growth and Spontaneous Metastasis in Orthotopic Murine Model of Breast Carcinoma
por: Fan, Bo, et al.
Publicado: (2017)

Combined Biomimetic MOF-RVG15 Nanoformulation Efficient Over BBB for Effective Anti-Glioblastoma in Mice Model
por: Wu, Hao, et al.
Publicado: (2022)

Co-delivery of VEGF siRNA and Etoposide for Enhanced Anti-angiogenesis and Anti-proliferation Effect via Multi-functional Nanoparticles for Orthotopic Non-Small Cell Lung Cancer Treatment
por: Li, Fang, et al.
Publicado: (2019)

siRNA-loaded poly(histidine-arginine)(6)-modified chitosan nanoparticle with enhanced cell-penetrating and endosomal escape capacities for suppressing breast tumor metastasis
por: Sun, Ping, et al.
Publicado: (2017)

Novel Fluorinated Spermine and Small Molecule PEI to Deliver Anti-PD-L1 and Anti-VEGF siRNA for Highly Efficient Tumor Therapy
por: Zhang, Yihui, et al.
Publicado: (2021)

Biomimetic and temporal-controlled nanocarriers with ileum transporter targeting for achieving oral administration of chemotherapeutic drugs
por: Liu, Wei, et al.
Publicado: (2022)

Correction: Biomimetic and temporal-controlled nanocarriers with ileum transporter targeting for achieving oral administration of chemotherapeutic drugs
por: Liu, Wei, et al.
Publicado: (2022)

Triple Cross‐linked Dynamic Responsive Hydrogel Loaded with Selenium Nanoparticles for Modulating the Inflammatory Microenvironment via PI3K/Akt/NF‐κB and MAPK Signaling Pathways
por: Wang, Shuangqing, et al.
Publicado: (2023)

Repurposing antifungals: population pharmacokinetics of itraconazole and hydroxy-itraconazole following administration of a nanocrystal formulation
por: Jansen, Anouk M E, et al.
Publicado: (2023)

Anti-angiogenic efficacy of 5′-triphosphate siRNA combining VEGF silencing and RIG-I activation in NSCLCs
por: Yuan, Dongmei, et al.
Publicado: (2015)

Research advances in peptide‒drug conjugates
por: Gong, Liming, et al.
Publicado: (2023)

Anti-VEGF Agents for Ocular Angiogenesis and Vascular Permeability
por: Kimoto, Kenichi, et al.
Publicado: (2012)

Development of Novel Paclitaxel-Loaded ZIF-8 Metal-Organic Framework Nanoparticles Modified with Peptide Dimers and an Evaluation of Its Inhibitory Effect against Prostate Cancer Cells
por: Zhao, Heming, et al.
Publicado: (2023)

Dual pH-Responsive and Tumor-Targeted Nanoparticle-Mediated Anti-Angiogenesis siRNA Delivery for Tumor Treatment
por: Zhang, Xiangyang, et al.
Publicado: (2022)

Co-delivery of paclitaxel and anti-VEGF siRNA by tripeptide lipid nanoparticle to enhance the anti-tumor activity for lung cancer therapy
por: Zhang, Chuanmin, et al.
Publicado: (2020)

Inhibition of retinal neovascularization by siRNA targeting VEGF(165)
por: Xia, Xiao-bo, et al.
Publicado: (2008)

Repurposing Itraconazole and Hydroxychloroquine to Target Lysosomal Homeostasis in Epithelial Ovarian Cancer
por: Marastoni, Stefano, et al.
Publicado: (2022)

VEGF Spliced Variants: Possible Role of Anti-Angiogenesis Therapy
por: Hilmi, Caroline, et al.
Publicado: (2012)

The anti-cancer effects of itraconazole in epithelial ovarian cancer
por: Choi, Chel Hun, et al.
Publicado: (2017)

Versatile flexible micelles integrating mucosal penetration and intestinal targeting for effectively oral delivery of paclitaxel
por: Liu, Chao, et al.
Publicado: (2023)

Thermo-responsive hydrogel as an anti-VEGF drug delivery system to inhibit retinal angiogenesis in Rex rabbits
por: Hu, Chao-Chien, et al.
Publicado: (2019)

Delivery of siRNA Using Functionalized Gold Nanorods Enhances Anti-Osteosarcoma Efficacy
por: Zhang, Man, et al.
Publicado: (2021)

Inhibition of ABCB1 (MDR1) Expression by an siRNA Nanoparticulate Delivery System to Overcome Drug Resistance in Osteosarcoma
por: Susa, Michiro, et al.
Publicado: (2010)

VEGF siRNA delivered by polycation liposome-encapsulated calcium phosphate nanoparticles for tumor angiogenesis inhibition in breast cancer
por: Chen, Jinliang, et al.
Publicado: (2017)

LA67 Liposome-Loaded Thermo-Sensitive Hydrogel with Active Targeting for Efficient Treatment of Keloid via Peritumoral Injection
por: Wan, Hongshuang, et al.
Publicado: (2023)

Antibody Targeting of Cathepsin S Inhibits Angiogenesis and Synergistically Enhances Anti-VEGF
por: Ward, Claire, et al.
Publicado: (2010)

Doxorubicin and anti-VEGF siRNA co-delivery via nano-graphene oxide for enhanced cancer therapy in vitro and in vivo
por: Sun, Qi, et al.
Publicado: (2018)

Emodin-Loaded Magnesium Silicate Hollow Nanocarriers for Anti-Angiogenesis Treatment through Inhibiting VEGF
por: Ren, Hua, et al.
Publicado: (2014)

Multifunctional oral delivery systems for enhanced bioavailability of therapeutic peptides/proteins
por: Han, Ying, et al.
Publicado: (2019)

Lipid-Based Nanoparticulate Systems for the Ocular Delivery of Bioactives with Anti-Inflammatory Properties
por: da Ana, Raquel, et al.
Publicado: (2022)

Modulation of angiogenesis with siRNA inhibitors for novel therapeutics
por: Lu, Patrick Y., et al.
Publicado: (2005)

Low-weight polyethylenimine cross-linked 2-hydroxypopyl-β-cyclodextrin and folic acid as an efficient and nontoxic siRNA carrier for gene silencing and tumor inhibition by VEGF siRNA
por: Li, Jin-Ming, et al.
Publicado: (2013)

Progress and Challenges of Anti-VEGF Agents and Their Sustained-Release Strategies for Retinal Angiogenesis
por: Xu, Manhong, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ehsjikkvrecica5tf236v2g796