Synthesis and Evaluation of Some New 4H-Pyran Derivatives as Antioxidant, Antibacterial and Anti-HCT-116 Cells of CRC, with Molecular Docking, Antiproliferative, Apoptotic and ADME Investigations

Colorectal cancer oncogenesis is linked to dysbiosis, oxidative stress and overexpression of CDK2. The 4H-pyran scaffold is considered an antitumoral, antibacterial and antioxidant lead as well as a CDK2 inhibitor. Herein, certain 4H-pyran derivatives were evaluated as antibacterial, antioxidant and...

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Detalles Bibliográficos
Autores principales: El-Sayed, Nahed N. E., Zaki, Magdi E. A., Al-Hussain, Sami A., Ben Bacha, Abir, Berredjem, Malika, Masand, Vijay H., Almarhoon, Zainab M., Omar, Hanaa S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317316/
https://www.ncbi.nlm.nih.gov/pubmed/35890189
http://dx.doi.org/10.3390/ph15070891

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317316/
https://www.ncbi.nlm.nih.gov/pubmed/35890189
http://dx.doi.org/10.3390/ph15070891

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