Increased Acetylcholine Levels and Other Brain Effects in 5XFAD Mice after Treatment with 8,14-Dihydroxy Metabolite of Efavirenz

Efavirenz (EFV), an FDA-approved anti-HIV drug, has off-target binding to CYP46A1, the CNS enzyme which converts cholesterol to 24-hydroxycholesterol. At small doses, EFV allosterically activates CYP46A1 in mice and humans and mitigates some of the Alzheimer’s disease manifestations in 5XFAD mice, a...

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Detalles Bibliográficos
Autores principales: Mast, Natalia, Li, Yong, Pikuleva, Irina A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317559/
https://www.ncbi.nlm.nih.gov/pubmed/35887013
http://dx.doi.org/10.3390/ijms23147669

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317559/
https://www.ncbi.nlm.nih.gov/pubmed/35887013
http://dx.doi.org/10.3390/ijms23147669

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