Mechanistic Insights into the Mechanism of Inhibitor Selectivity toward the Dark Kinase STK17B against Its High Homology STK17A

As a member of the death-associated protein kinase (DAPK) family, STK17B plays an important role in the regulation of cellular apoptosis and has been considered as a promising drug target for hepatocellular carcinoma. However, the highly conserved ATP-binding site of protein kinases represents a cha...

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Detalles Bibliográficos
Autores principales: Liu, Chang, Zhang, Yichi, Zhang, Yuqing, Liu, Zonghan, Mao, Feifei, Chai, Zongtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317881/
https://www.ncbi.nlm.nih.gov/pubmed/35889528
http://dx.doi.org/10.3390/molecules27144655

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317881/
https://www.ncbi.nlm.nih.gov/pubmed/35889528
http://dx.doi.org/10.3390/molecules27144655

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