Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator

The AMP-activated protein kinase (AMPK) αβγ heterotrimer is a primary cellular energy sensor and central regulator of energy homeostasis. Activating skeletal muscle AMPK with small molecule drugs improves glucose uptake and provides an opportunity for new strategies to treat type 2 diabetes and insu...

Descripción completa

Detalles Bibliográficos
Autores principales: Ovens, Ashley J., Gee, Yi Sing, Ling, Naomi X.Y., Yu, Dingyi, Hardee, Justin P., Chung, Jin D., Ngoei, Kevin R.W., Waters, Nicholas J., Hoffman, Nolan J., Scott, John W., Loh, Kim, Spengler, Katrin, Heller, Regine, Parker, Michael W., Lynch, Gordon S., Huang, Fei, Galic, Sandra, Kemp, Bruce E., Baell, Jonathan B., Oakhill, Jonathan S., Langendorf, Christopher G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2022
Materias:
Diabetes & Metabolic Disorders
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317966/
https://www.ncbi.nlm.nih.gov/pubmed/35552369
http://dx.doi.org/10.1042/BCJ20220067

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317966/
https://www.ncbi.nlm.nih.gov/pubmed/35552369
http://dx.doi.org/10.1042/BCJ20220067

Ejemplares similares