Cargando…

Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator

The AMP-activated protein kinase (AMPK) αβγ heterotrimer is a primary cellular energy sensor and central regulator of energy homeostasis. Activating skeletal muscle AMPK with small molecule drugs improves glucose uptake and provides an opportunity for new strategies to treat type 2 diabetes and insu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ovens, Ashley J., Gee, Yi Sing, Ling, Naomi X.Y., Yu, Dingyi, Hardee, Justin P., Chung, Jin D., Ngoei, Kevin R.W., Waters, Nicholas J., Hoffman, Nolan J., Scott, John W., Loh, Kim, Spengler, Katrin, Heller, Regine, Parker, Michael W., Lynch, Gordon S., Huang, Fei, Galic, Sandra, Kemp, Bruce E., Baell, Jonathan B., Oakhill, Jonathan S., Langendorf, Christopher G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2022
Materias:	Diabetes & Metabolic Disorders
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317966/ https://www.ncbi.nlm.nih.gov/pubmed/35552369 http://dx.doi.org/10.1042/BCJ20220067

Ejemplares similares

AMPK protects endothelial cells against HSV-1 replication via inhibition of mTORC1 and ACC1
por: Doshi, Heena, et al.
Publicado: (2023)

Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding
por: Langendorf, Christopher G., et al.
Publicado: (2016)

The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs
por: Dite, Toby A., et al.
Publicado: (2017)

mTORC1 directly inhibits AMPK to promote cell proliferation under nutrient stress
por: Ling, Naomi X.Y., et al.
Publicado: (2020)

Genetic loss of AMPK-glycogen binding destabilises AMPK and disrupts metabolism
por: Hoffman, Nolan J., et al.
Publicado: (2020)

Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1-isoforms
por: Pinkosky, Stephen L., et al.
Publicado: (2020)

Post-Translational Modifications of the Energy Guardian AMP-Activated Protein Kinase
por: Ovens, Ashley J., et al.
Publicado: (2021)

Import of extracellular ATP in yeast and man modulates AMPK and TORC1 signalling
por: Forte, Gabriella M., et al.
Publicado: (2019)

CaMKK2 is not involved in contraction-stimulated AMPK activation and glucose uptake in skeletal muscle
por: Negoita, Florentina, et al.
Publicado: (2023)

IQGAP1 binds AMPK and is required for maximum AMPK activation
por: Hedman, Andrew C., et al.
Publicado: (2020)

Relationships between Mitochondrial Function, AMPK, and TORC1 Signaling in Lymphoblasts with Premutation Alleles of the FMR1 Gene
por: Fisher, Paul R., et al.
Publicado: (2021)

The myokine meteorin‐like (metrnl) improves glucose tolerance in both skeletal muscle cells and mice by targeting AMPKα2
por: Lee, Jung Ok, et al.
Publicado: (2020)

Fyn phosphorylates AMPK to inhibit AMPK activity and AMP-dependent activation of autophagy
por: Yamada, Eijiro, et al.
Publicado: (2016)

Mechanism of Activation of AMPK by Cordycepin
por: Hawley, Simon A., et al.
Publicado: (2020)

Salicylate improves macrophage cholesterol homeostasis via activation of Ampk
por: Fullerton, Morgan D., et al.
Publicado: (2015)

STIM2 interacts with AMPK and regulates calcium-induced AMPK activation
por: Chauhan, Anoop Singh, et al.
Publicado: (2019)

VEGF Triggers Transient Induction of Autophagy in Endothelial Cells via AMPKα1
por: Spengler, Katrin, et al.
Publicado: (2020)

Cellular Bioenergetics and AMPK and TORC1 Signalling in Blood Lymphoblasts Are Biomarkers of Clinical Status in FMR1 Premutation Carriers
por: Loesch, Danuta Z., et al.
Publicado: (2021)

Mutant TDP-43 Deregulates AMPK Activation by PP2A in ALS Models
por: Perera, Nirma D., et al.
Publicado: (2014)

AMPK Activation: Respiratory Panacea?
por: Plataki, Maria, et al.
Publicado: (2022)

Synphilin-1 Interacts with AMPK and Increases AMPK Phosphorylation
por: Li, Tianxia, et al.
Publicado: (2020)

Compound- and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle
por: Rhein, Philipp, et al.
Publicado: (2021)

β-GPA: AN AMPK ACTIVATOR WITH POTENTIAL EFFECTS ON HEALTHSPAN AND FUNCTION
por: Dorigatti, Jonathan, et al.
Publicado: (2019)

AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis
por: Galic, Sandra, et al.
Publicado: (2018)

AMPK activators: mechanisms of action and physiological activities
por: Kim, Joungmok, et al.
Publicado: (2016)

Modeling Structure–Activity Relationship of AMPK Activation
por: Drewe, Jürgen, et al.
Publicado: (2021)

AMPK activation can delay aging
por: Stancu, Andreea L.
Publicado: (2015)

Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms
por: Chen, Suet Ching, et al.
Publicado: (2017)

Epe1 contributes to activation of AMPK by promoting phosphorylation of AMPK alpha subunit, Ssp2
por: Chen, Yongyi, et al.
Publicado: (2017)

Novel indolic AMPK modulators induce vasodilatation through activation of the AMPK–eNOS–NO pathway
por: Sanz-Gómez, Marta, et al.
Publicado: (2022)

AMPK β1 reduces tumor progression and improves survival in p53 null mice
por: Houde, Vanessa P., et al.
Publicado: (2017)

The Role of AMPK Activation for Cardioprotection in Doxorubicin-Induced Cardiotoxicity
por: Timm, Kerstin N., et al.
Publicado: (2020)

Activation of AMPK by Bitter Melon Triterpenoids Involves CaMKKβ
por: Iseli, Tristan J., et al.
Publicado: (2013)

Structural basis of AMPK regulation by small molecule activators
por: Xiao, Bing, et al.
Publicado: (2013)

Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965
por: Ahwazi, Danial, et al.
Publicado: (2021)

AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review
por: Višnjić, Dora, et al.
Publicado: (2021)

Defective AMPK regulation of cholesterol metabolism accelerates atherosclerosis by promoting HSPC mobilization and myelopoiesis
por: Lee, Man K.S., et al.
Publicado: (2022)

Madagascine Induces Vasodilatation via Activation of AMPK
por: Chen, Dapeng, et al.
Publicado: (2016)

AMPK activates DAPK2 to promote autophagy
por: Shiloh, Ruth, et al.
Publicado: (2018)

Natural AMPK Activators in Cardiovascular Disease Prevention
por: Heidary Moghaddam, Reza, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_infl5085i4lg1lc0pa11pt29dc