Mechanosensitive Channel PIEZO1 Senses Shear Force to Induce KLF2/4 Expression via CaMKII/MEKK3/ERK5 Axis in Endothelial Cells

Shear stress exerted by the blood stream modulates endothelial functions through altering gene expression. KLF2 and KLF4, the mechanosensitive transcription factors, are promoted by laminar flow to maintain endothelial homeostasis. However, how the expression of KLF2/4 is regulated by shear stress i...

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Detalles Bibliográficos
Autores principales: Zheng, Qi, Zou, Yonggang, Teng, Peng, Chen, Zhenghua, Wu, Yuefeng, Dai, Xiaoyi, Li, Xiya, Hu, Zonghao, Wu, Shengjun, Xu, Yanhua, Zou, Weiguo, Song, Hai, Ma, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317998/
https://www.ncbi.nlm.nih.gov/pubmed/35883633
http://dx.doi.org/10.3390/cells11142191

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317998/
https://www.ncbi.nlm.nih.gov/pubmed/35883633
http://dx.doi.org/10.3390/cells11142191

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