Hybridization Approach to Identify Salicylanilides as Inhibitors of Tubulin Polymerization and Signal Transducers and Activators of Transcription 3 (STAT3)

The superimposition of the X-ray complexes of cyclohexanediones (i.e., TUB015), described by our research group, and nocodazole, within the colchicine binding site of tubulin provided an almost perfect overlap of both ligands. This structural information led us to propose hybrids of TUB015 and nocod...

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Detalles Bibliográficos
Autores principales: Gargantilla, Marta, Persoons, Leentje, Kauerová, Tereza, del Río, Natalia, Daelemans, Dirk, Priego, Eva-María, Kollar, Peter, Pérez-Pérez, María-Jesús
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9318074/
https://www.ncbi.nlm.nih.gov/pubmed/35890135
http://dx.doi.org/10.3390/ph15070835

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9318074/
https://www.ncbi.nlm.nih.gov/pubmed/35890135
http://dx.doi.org/10.3390/ph15070835

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