Improving Drug Sensitivity of HIV-1 Protease Inhibitors by Restriction of Cellular Efflux System in a Fission Yeast Model

Fission yeast can be used as a cell-based system for high-throughput drug screening. However, higher drug concentrations are often needed to achieve the same effect as in mammalian cells. Our goal here was to improve drug sensitivity so reduced drugs could be used. Three different methods affecting...

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Detalles Bibliográficos
Autores principales: Zhang, Jiantao, Li, Qi, Kawashima, Shigehiro A., Nasr, Mohamed, Xue, Fengtian, Zhao, Richard Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9318301/
https://www.ncbi.nlm.nih.gov/pubmed/35890048
http://dx.doi.org/10.3390/pathogens11070804

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9318301/
https://www.ncbi.nlm.nih.gov/pubmed/35890048
http://dx.doi.org/10.3390/pathogens11070804

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