Optimization of 2-Aminoquinazolin-4-(3H)-one Derivatives as Potent Inhibitors of SARS-CoV-2: Improved Synthesis and Pharmacokinetic Properties

We previously reported the potent antiviral effect of the 2-aminoquinazolin-4-(3H)-one 1, which shows significant activity (IC(50) = 0.23 μM) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with no cytotoxicity. However, it is necessary to improve the in vivo pharmacokinetics of...

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Detalles Bibliográficos
Autores principales: Shin, Young Sup, Lee, Jun Young, Jeon, Sangeun, Cho, Jung-Eun, Myung, Subeen, Jang, Min Seong, Kim, Seungtaek, Song, Jong Hwan, Kim, Hyoung Rae, Park, Hyeung-geun, Jeong, Lak Shin, Park, Chul Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9318802/
https://www.ncbi.nlm.nih.gov/pubmed/35890130
http://dx.doi.org/10.3390/ph15070831

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9318802/
https://www.ncbi.nlm.nih.gov/pubmed/35890130
http://dx.doi.org/10.3390/ph15070831

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