Intensification of Double Kinetic Resolution of Chiral Amines and Alcohols via Chemoselective Formation of a Carbonate–Enzyme Intermediate

Chiral amines and alcohols are synthons of numerous pharmaceutically-relevant compounds. The previously developed enzymatic kinetic resolution approaches utilize a chiral racemic molecule and achiral acyl donor (or acyl acceptor). Thus, only one enantiodivergent step of the catalytic cycle is engage...

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Detalles Bibliográficos
Autores principales: Samsonowicz-Górski, Jan, Brodzka, Anna, Ostaszewski, Ryszard, Koszelewski, Dominik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319036/
https://www.ncbi.nlm.nih.gov/pubmed/35889218
http://dx.doi.org/10.3390/molecules27144346

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319036/
https://www.ncbi.nlm.nih.gov/pubmed/35889218
http://dx.doi.org/10.3390/molecules27144346

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