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Intensification of Double Kinetic Resolution of Chiral Amines and Alcohols via Chemoselective Formation of a Carbonate–Enzyme Intermediate

Chiral amines and alcohols are synthons of numerous pharmaceutically-relevant compounds. The previously developed enzymatic kinetic resolution approaches utilize a chiral racemic molecule and achiral acyl donor (or acyl acceptor). Thus, only one enantiodivergent step of the catalytic cycle is engage...

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Detalles Bibliográficos
Autores principales:	Samsonowicz-Górski, Jan, Brodzka, Anna, Ostaszewski, Ryszard, Koszelewski, Dominik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319036/ https://www.ncbi.nlm.nih.gov/pubmed/35889218 http://dx.doi.org/10.3390/molecules27144346

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