Cargando…

Self-Emulsifying Drug Delivery Systems: An Alternative Approach to Improve Brain Bioavailability of Poorly Water-Soluble Drugs through Intranasal Administration

Efforts in discovering new and effective neurotherapeutics are made daily, although most fail to reach clinical trials. The main reason is their poor bioavailability, related to poor aqueous solubility, limited permeability through biological membranes, and the hepatic first-pass metabolism. Neverth...

Descripción completa

Detalles Bibliográficos
Autores principales:	Meirinho, Sara, Rodrigues, Márcio, Santos, Adriana O., Falcão, Amílcar, Alves, Gilberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319231/ https://www.ncbi.nlm.nih.gov/pubmed/35890385 http://dx.doi.org/10.3390/pharmaceutics14071487

Ejemplares similares

Intranasal Microemulsion as an Innovative and Promising Alternative to the Oral Route in Improving Stiripentol Brain Targeting
por: Meirinho, Sara, et al.
Publicado: (2023)

Liquid chromatographic methods for determination of the new antiepileptic drugs stiripentol, retigabine, rufinamide and perampanel: A comprehensive and critical review
por: Meirinho, Sara, et al.
Publicado: (2021)

Self-emulsifying drug delivery systems as a tool to improve solubility and bioavailability of resveratrol
por: Balata, Gehan F, et al.
Publicado: (2016)

Strategies to Enhance the Solubility and Bioavailability of Tocotrienols Using Self-Emulsifying Drug Delivery System
por: Mohamad, Nur-Vaizura
Publicado: (2023)

Editorial: Intranasal Delivery of Central Nervous System Active Drugs: Opportunities and Challenges
por: Rodrigues, Márcio, et al.
Publicado: (2022)

Herb-Drug Interaction of Paullinia cupana (Guarana) Seed Extract on the Pharmacokinetics of Amiodarone in Rats
por: Rodrigues, Márcio, et al.
Publicado: (2012)

Strategies to Improve Drug Strength in Nasal Preparations for Brain Delivery of Low Aqueous Solubility Drugs
por: Pires, Patrícia C., et al.
Publicado: (2022)

Nanocrystals of Poorly Soluble Drugs: Drug Bioavailability and Physicochemical Stability
por: Gigliobianco, Maria Rosa, et al.
Publicado: (2018)

The preparation and relative bioavailability of an artemisin in self-emulsifying drug delivery system
por: Gao, Sijia, et al.
Publicado: (2023)

Formulation Strategies to Improve the Bioavailability of Poorly Absorbed Drugs with Special Emphasis on Self-Emulsifying Systems
por: Gupta, Shweta, et al.
Publicado: (2013)

Polymorph Impact on the Bioavailability and Stability of Poorly Soluble Drugs
por: Censi, Roberta, et al.
Publicado: (2015)

Encapsulated Escitalopram and Paroxetine Intranasal Co-Administration: In Vitro/In Vivo Evaluation
por: Silva, Soraia, et al.
Publicado: (2021)

Supersaturation-Based Drug Delivery Systems: Strategy for Bioavailability Enhancement of Poorly Water-Soluble Drugs
por: Sharma, Arvind, et al.
Publicado: (2022)

Cocrystal of Apixaban–Quercetin: Improving Solubility and Bioavailability of Drug Combination of Two Poorly Soluble Drugs
por: Zhang, Li, et al.
Publicado: (2021)

Supramolecular Complexation of Carbohydrates for the Bioavailability Enhancement of Poorly Soluble Drugs
por: Cho, Eunae, et al.
Publicado: (2015)

Nanocrystalization: An Emerging Technology to Enhance the  Bioavailability of Poorly Soluble Drugs
por: Joshi, Kavita, et al.
Publicado: (2019)

Bioavailability Enhancement Techniques for Poorly Aqueous Soluble Drugs and Therapeutics
por: Bhalani, Dixit V., et al.
Publicado: (2022)

Systematic Development of Self-Emulsifying Drug Delivery Systems of Atorvastatin with Improved Bioavailability Potential
por: Khan, Fariba, et al.
Publicado: (2012)

Polymeric Micelles, a Promising Drug Delivery System to Enhance Bioavailability of Poorly Water-Soluble Drugs
por: Xu, Wei, et al.
Publicado: (2013)

Development of self-nanoemulsifying drug delivery systems for the enhancement of solubility and oral bioavailability of fenofibrate, a poorly water-soluble drug
por: Mohsin, Kazi, et al.
Publicado: (2016)

The utility of self-emulsifying oil formulation to improve the poor solubility of the anti HIV drug CSIC
por: Obitte, Nicholas C, et al.
Publicado: (2013)

Functions of Lipids for Enhancement of Oral Bioavailability of Poorly Water-Soluble Drugs
por: Nanjwade, Basavaraj K., et al.
Publicado: (2011)

Enhanced oral bioavailability of oligomeric proanthocyanidins by a self‐double‐emulsifying drug delivery system
por: Tian, Yuan, et al.
Publicado: (2020)

Pharmaceutical Dispersion Techniques for Dissolution and Bioavailability Enhancement of Poorly Water-Soluble Drugs
por: Zhang, Xingwang, et al.
Publicado: (2018)

Insoluble Polymers in Solid Dispersions for Improving Bioavailability of Poorly Water-Soluble Drugs
por: Tran, Thao T.D., et al.
Publicado: (2020)

Formulation optimization of Docetaxel loaded self-emulsifying drug delivery system to enhance bioavailability and anti-tumor activity
por: Valicherla, Guru R., et al.
Publicado: (2016)

Nanotechnology Based Approaches for Enhancing Oral Bioavailability of Poorly Water Soluble Antihypertensive Drugs
por: Sharma, Mayank, et al.
Publicado: (2016)

Improved Bioavailability of Poorly Soluble Drugs through Gastrointestinal Muco-Adhesion of Lipid Nanoparticles
por: Tan, Sui Ling Janet, et al.
Publicado: (2021)

Advancement in Solubilization Approaches: A Step towards Bioavailability Enhancement of Poorly Soluble Drugs
por: Kumari, Lakshmi, et al.
Publicado: (2023)

Improved Bioavailability of Poorly Water-Soluble Drug by Targeting Increased Absorption through Solubility Enhancement and Precipitation Inhibition
por: Lee, Ju-Hyun, et al.
Publicado: (2021)

Improved oral bioavailability of poorly water-soluble indirubin by a supersaturatable self-microemulsifying drug delivery system
por: Chen, Zhi-Qiang, et al.
Publicado: (2012)

Enhanced Bioavailability of Tadalafil after Intranasal Administration in Beagle Dogs
por: Kim, Jeong-Soo, et al.
Publicado: (2018)

Bioavailability Enhancement of Poorly Water-Soluble Drugs via Nanocomposites: Formulation–Processing Aspects and Challenges
por: Bhakay, Anagha, et al.
Publicado: (2018)

Ileo-Colon Targeting of the Poorly Water-Soluble Drug Celecoxib Using a pH-Dependent Coating in Combination with Self-Emulsifying Drug Delivery or Solid Dispersion Systems
por: Broesder, Annemarie, et al.
Publicado: (2021)

Cosolvents in Self-Emulsifying Drug Delivery Systems (SEDDS): Do They Really Solve Our Solubility Problems?
por: Jörgensen, Arne Matteo, et al.
Publicado: (2020)

Potentially Inappropriate Medications and Potential Prescribing Omissions in Elderly Patients Receiving Post-Acute and Long-Term Care: Application of Screening Tool of Older People’s Prescriptions/Screening Tool to Alert to Right Treatment Criteria
por: Candeias, Catarina, et al.
Publicado: (2021)

Oral Bioavailability and Lymphatic Transport of Pueraria Flavone-Loaded Self-Emulsifying Drug-Delivery Systems Containing Sodium Taurocholate in Rats
por: Qiao, Jin, et al.
Publicado: (2018)

In vitro evaluation of a self-emulsifying drug delivery system (SEDDS) for nasal administration of dimenhydrinate
por: Leichner, Christina, et al.
Publicado: (2019)

Self-Nanoemulsifying Drug Delivery Systems for Enhancing Solubility, Permeability, and Bioavailability of Sesamin
por: Wang, Chih-Yuan, et al.
Publicado: (2020)

Self-emulsifying micelles as a drug nanocarrier system for itraconazole oral bioavailability enhancement; in vitro and in vivo assessment
por: Islam, Nayyer, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_18gf4lrcvdl6nj3p0rdcb920nl